Effect of adjuvant drugs on the analgesic activity of opioid morphine analgesics and compound RU-1205

Introduction: Adjuvant medications can be used to increase the analgesic effect of opioid analgesics, reduce manifestation side effects, and also for premedication. This paper provides information on clonidine, haloperidol, metocloparmide, diazepam, midazolam analgesics: - morphine selective kappa-opioid agonist compound RU-1205.
 Materials methods: A probable interaction between RU-1205, adjuvant drugs in pain behaviors was carried out model somatogenic pain. 95 male mice received either RU-1205 (5 mg/kg, i.p.) (1 separately or combination with haloperidol (0.45 i.p.); (0.3 diazepam metoclopramide i.p.), clonidine i.p.). The assessed by tail flick test. Registration latent period reaction 30, 60 90 minutes after drug administration.
 Results: When studying morphine, it found that enhanced effects; offset them, had no affect properties. In course studies, showed an activity when combined a slight midazolam, decrease co-administered diazepam. Haloperidol influence while both potentiated reduced effect.
 Discussion: Pharmacodynamic pharmacokinetic interactions α2AR agonist, benzodiazepine receptor agonists, D2P antagonist, σ-receptor blocker were established.
 Conclusion: presented data make possible more accurately formulate ideas about localization action mechanism kappa-agonist receptors, RU-1205.